Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 412)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0364034	0.0998204	0.7189901
Weighted median	23	0.0145004	0.0568740	0.7987572
Inverse variance weighted	23	0.0005303	0.0390156	0.9891556
Simple mode	23	0.0020663	0.0949506	0.9828342
Weighted mode	23	0.0172462	0.0614461	0.7815847

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.63317	21	0.5445914
Inverse variance weighted	19.78561	22	0.5964486

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002203	0.0056423	0.7001468

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005996	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8