Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 411)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0442066	0.0998207	0.6623951
Weighted median	23	0.0617877	0.0556193	0.2666103
Inverse variance weighted	23	0.0050360	0.0390157	0.8972983
Simple mode	23	0.0828406	0.0915874	0.3755300
Weighted mode	23	0.0677774	0.0659893	0.3155366

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.61336	21	0.8418409
Inverse variance weighted	14.79511	22	0.8708797

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024055	0.0056423	0.6742101

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004488	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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