Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 410)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0379224	0.0998199	0.7078282
Weighted median	23	-0.0586285	0.0587862	0.3186099
Inverse variance weighted	23	-0.0076058	0.0390154	0.8454377
Simple mode	23	-0.1062012	0.1089936	0.3404608
Weighted mode	23	-0.0630032	0.0814163	0.4472616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.90216	21	0.6551870
Inverse variance weighted	18.14770	22	0.6971959

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027959	0.0056423	0.6253772

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005511	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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