Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 41)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1477398	0.1008259	0.1576530
Weighted median	23	-0.1125508	0.0540915	0.0374568
Inverse variance weighted	23	-0.0699008	0.0391420	0.0741273
Simple mode	23	-0.0554612	0.0939788	0.5611062
Weighted mode	23	-0.1160561	0.0615018	0.0724214

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.42548	21	0.4332372
Inverse variance weighted	22.14321	22	0.4513689

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047801	0.0056992	0.4110645

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007683	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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