Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 409)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2094281	0.0998201	0.0481772
Weighted median	23	-0.1005865	0.0541620	0.0632912
Inverse variance weighted	23	-0.0466798	0.0402569	0.2462333
Simple mode	23	-0.0903879	0.0856401	0.3026779
Weighted mode	23	-0.1143836	0.0654638	0.0945357

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.28495	21	0.5032821
Inverse variance weighted	23.42253	22	0.3782093

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0099944	0.0056424	0.0910206

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007531	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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