Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 408)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0343779	0.1256883	0.7871275
Weighted median	23	0.0296258	0.0562123	0.5981701
Inverse variance weighted	23	0.0299550	0.0479985	0.5325738
Simple mode	23	0.0780522	0.0888460	0.3891610
Weighted mode	23	0.0505331	0.0624360	0.4269759

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.29487	21	0.043048
Inverse variance weighted	33.29719	22	0.057814

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002716	0.0071045	0.9698647

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010268	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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