Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 407)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1070948	0.0998199	0.2954996
Weighted median	23	-0.0028656	0.0581040	0.9606662
Inverse variance weighted	23	-0.0271110	0.0390154	0.4871306
Simple mode	23	-0.2088911	0.1152921	0.0836845
Weighted mode	23	0.0162870	0.0750008	0.8300870

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.45548	21	0.5559464
Inverse variance weighted	21.58905	22	0.4846337

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0082416	0.0056423	0.1589057

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006689	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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