Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 406)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1333673	0.1141476	0.2557487
Weighted median	23	-0.1264514	0.0542327	0.0197193
Inverse variance weighted	23	-0.0404876	0.0443938	0.3617642
Simple mode	23	-0.1240520	0.0867795	0.1669060
Weighted mode	23	-0.1299993	0.0721558	0.0853230

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.46194	21	0.1560809
Inverse variance weighted	28.48387	22	0.1601944

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0057038	0.0064522	0.3867032

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008957	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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