Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 405)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0546398	0.1350765	0.6899281
Weighted median	23	-0.0320121	0.0566761	0.5721931
Inverse variance weighted	23	0.0025182	0.0518403	0.9612567
Simple mode	23	-0.0254362	0.1058688	0.8123521
Weighted mode	23	-0.0623627	0.0615741	0.3221624

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.45373	21	0.0113975
Inverse variance weighted	38.84073	22	0.0147165

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00351	0.0076351	0.6504391

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001177	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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