Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 404)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1048932	0.0998207	0.3052856
Weighted median	23	0.0259518	0.0529529	0.6240682
Inverse variance weighted	23	-0.0270248	0.0390157	0.4885201
Simple mode	23	0.0258560	0.0979030	0.7941621
Weighted mode	23	0.0314632	0.0656893	0.6366864

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.80225	21	0.6614817
Inverse variance weighted	19.86367	22	0.5915672

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0081011	0.0056423	0.1657987

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006165	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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