Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 403)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1144966	0.0998206	0.2642726
Weighted median	23	0.0137430	0.0552200	0.8034560
Inverse variance weighted	23	0.0348575	0.0390156	0.3716304
Simple mode	23	-0.0175850	0.0909593	0.8484755
Weighted mode	23	-0.0019239	0.0680166	0.9776893

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.00690	21	0.9083821
Inverse variance weighted	15.64926	22	0.8329034

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0091718	0.0056423	0.1189631

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004984	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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