Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 402)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0797873	0.0998212	0.4330635
Weighted median	23	0.0258440	0.0530324	0.6260275
Inverse variance weighted	23	-0.0386123	0.0390159	0.3223419
Simple mode	23	-0.0103903	0.0846442	0.9034178
Weighted mode	23	0.0236261	0.0581222	0.6883097

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.75881	21	0.8348569
Inverse variance weighted	16.41936	22	0.7945419

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072709	0.0056424	0.2115448

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005272	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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