Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 401)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0869456	0.1190748	0.4733504
Weighted median	23	-0.0421011	0.0562113	0.4538697
Inverse variance weighted	23	-0.0052141	0.0460695	0.9098884
Simple mode	23	-0.1373538	0.0907851	0.1445251
Weighted mode	23	-0.0612446	0.0662802	0.3654980

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.88311	21	0.0943622
Inverse variance weighted	30.67441	22	0.1029728

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050191	0.0067306	0.4641099

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00093	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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