Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 400)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1991376	0.1163963	0.1018407
Weighted median	23	0.0214305	0.0595677	0.7190208
Inverse variance weighted	23	-0.0026561	0.0480562	0.9559235
Simple mode	23	-0.1456360	0.1260836	0.2604517
Weighted mode	23	0.0770636	0.0826942	0.3614980

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.55379	21	0.1251328
Inverse variance weighted	33.37748	22	0.0567577

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0123921	0.0065793	0.0735554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010116	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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