Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 40)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0016469	0.1056389	0.9877084
Weighted median	23	-0.0335820	0.0599507	0.5753708
Inverse variance weighted	23	-0.0009061	0.0403408	0.9820801
Simple mode	23	-0.0460265	0.1152443	0.6934627
Weighted mode	23	-0.1156221	0.0879907	0.2023744

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.52038	21	0.3168724
Inverse variance weighted	23.52045	22	0.3728586

Test for directional horizontal pleiotropy

egger_intercept	se	pval
4.55e-05	0.0059713	0.9939928

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007127	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8