Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 4)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0560558	0.1005354	0.5830318
Weighted median	23	0.0501102	0.0554847	0.3664537
Inverse variance weighted	23	0.0047890	0.0390154	0.9023088
Simple mode	23	0.1061931	0.0924042	0.2628051
Weighted mode	23	0.0654197	0.0660834	0.3329592

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.30208	21	0.4406335
Inverse variance weighted	21.61342	22	0.4831549

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031483	0.0056827	0.5854248

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006554	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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