Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 399)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0621755	0.1186507	0.6057511
Weighted median	23	-0.0162734	0.0581670	0.7796531
Inverse variance weighted	23	-0.0432057	0.0463029	0.3507637
Simple mode	23	0.0225405	0.0935019	0.8117333
Weighted mode	23	0.0087061	0.0658454	0.8960114

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.67057	21	0.0988104
Inverse variance weighted	30.98607	22	0.0964009

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064714	0.0067067	0.3455654

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009761	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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