Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 398)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1259081	0.1289242	0.3398815
Weighted median	23	-0.0107579	0.0659509	0.8704239
Inverse variance weighted	23	0.0069964	0.0506823	0.8902058
Simple mode	23	0.0552681	0.1272820	0.6683594
Weighted mode	23	0.0586820	0.1382719	0.6753985

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.03395	21	0.0279938
Inverse variance weighted	37.12653	22	0.0229105

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081618	0.0072875	0.2753737

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011259	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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