Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 396)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0529629	0.0998203	0.6012749
Weighted median	23	-0.0021197	0.0580978	0.9708951
Inverse variance weighted	23	-0.0420873	0.0390154	0.2807056
Simple mode	23	0.0111178	0.1073141	0.9184251
Weighted mode	23	0.0232104	0.0817551	0.7791404

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.51439	21	0.8465073
Inverse variance weighted	14.52840	22	0.8816700

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006679	0.0056424	0.9069017

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004755	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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