Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 395)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0128478	0.0998204	0.8988128
Weighted median	23	-0.0369119	0.0613957	0.5476977
Inverse variance weighted	23	-0.0188510	0.0390154	0.6289765
Simple mode	23	-0.0312479	0.0981770	0.7532737
Weighted mode	23	-0.0372728	0.0742210	0.6205253

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.52549	21	0.4882290
Inverse variance weighted	20.52976	22	0.5499387

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003687	0.0056424	0.948523

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006292	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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