Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 394)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0501421	0.0998206	0.6206675
Weighted median	23	-0.0160010	0.0539146	0.7666306
Inverse variance weighted	23	0.0177921	0.0390156	0.6483720
Simple mode	23	0.0059329	0.0952186	0.9508803
Weighted mode	23	-0.0148063	0.0753904	0.8461037

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.787793	21	0.9815376
Inverse variance weighted	9.911761	22	0.9870873

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019866	0.0056424	0.7282796

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003067	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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