Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 393)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1421318	0.1003451	0.1713132
Weighted median	23	0.0004173	0.0565586	0.9941132
Inverse variance weighted	23	0.0077311	0.0406502	0.8491632
Simple mode	23	0.0021726	0.0966446	0.9822679
Weighted mode	23	0.0130280	0.0711525	0.8563971

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.22194	21	0.4454640
Inverse variance weighted	23.88242	22	0.3534227

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0092031	0.005672	0.1196039

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007249	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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