Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 392)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1850202	0.0998185	0.0779039
Weighted median	23	-0.0796071	0.0543832	0.1432435
Inverse variance weighted	23	-0.0733651	0.0390152	0.0600502
Simple mode	23	-0.1279398	0.0980496	0.2054292
Weighted mode	23	-0.1205159	0.0655096	0.0793509

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.59208	21	0.8428500
Inverse variance weighted	16.06893	22	0.8124502

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068568	0.0056423	0.2377559

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005941	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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