Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 391)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0192880	0.1094857	0.8618490
Weighted median	23	-0.0317292	0.0594139	0.5933162
Inverse variance weighted	23	-0.0337124	0.0418300	0.4202779
Simple mode	23	0.0432722	0.1172535	0.7156199
Weighted mode	23	0.0725757	0.0964595	0.4597882

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.26419	21	0.2359033
Inverse variance weighted	25.28883	22	0.2834627

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008858	0.0061887	0.8875494

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007889	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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