Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 390)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0874801	0.0998196	0.3907377
Weighted median	23	0.0946246	0.0593745	0.1110052
Inverse variance weighted	23	0.0947103	0.0390151	0.0152020
Simple mode	23	0.0221903	0.1141195	0.8476095
Weighted mode	23	0.0935160	0.0683951	0.1853425

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.71254	21	0.4766154
Inverse variance weighted	20.71873	22	0.5381744

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000444	0.0056423	0.9380222

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008064	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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