Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 39)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0369216	0.1024548	0.7221702
Weighted median	23	-0.0481983	0.0555724	0.3857741
Inverse variance weighted	23	-0.0066626	0.0392204	0.8651073
Simple mode	23	0.1124545	0.0940544	0.2445691
Weighted mode	23	-0.0531257	0.0685371	0.4465107

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.12318	21	0.3924416
Inverse variance weighted	22.23164	22	0.4461375

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018582	0.0057912	0.7514847

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006746	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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