Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 389)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0675984	0.1074268	0.5359708
Weighted median	23	0.0654609	0.0640750	0.3069560
Inverse variance weighted	23	0.0246018	0.0418638	0.5567590
Simple mode	23	0.0695137	0.1105432	0.5359308
Weighted mode	23	0.1331291	0.1150553	0.2596461

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.32331	21	0.2776585
Inverse variance weighted	25.33033	22	0.2815402

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056621	0.0060723	0.3617092

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007796	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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