Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 388)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0127121	0.1027382	0.9027032
Weighted median	23	-0.0184411	0.0541709	0.7335372
Inverse variance weighted	23	-0.0087235	0.0392345	0.8240469
Simple mode	23	-0.0184902	0.0876603	0.8348833
Weighted mode	23	-0.0249850	0.0569854	0.6653389

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.24561	21	0.3854766
Inverse variance weighted	22.24750	22	0.4452017

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002449	0.0058072	0.9667551

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006756	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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