Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 387)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0773675	0.1014668	0.4542472
Weighted median	23	0.0589070	0.0564168	0.2964212
Inverse variance weighted	23	0.0155202	0.0396494	0.6954758
Simple mode	23	0.0163651	0.0955587	0.8655872
Weighted mode	23	0.0293021	0.0652544	0.6577928

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.69865	21	0.4170499
Inverse variance weighted	22.72072	22	0.4176403

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0057042	0.0057354	0.3312704

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006933	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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