Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 386)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0861657	0.0998201	0.3977735
Weighted median	23	0.0583021	0.0528843	0.2702678
Inverse variance weighted	23	0.0266266	0.0390156	0.4949481
Simple mode	23	0.0467808	0.0994280	0.6426291
Weighted mode	23	0.0645794	0.0723865	0.3819685

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.23301	21	0.9580547
Inverse variance weighted	11.65293	22	0.9641382

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036563	0.0056423	0.5239985

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003672	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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