Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 385)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0336794	0.1074115	0.7569523
Weighted median	23	0.0259536	0.0581492	0.6553606
Inverse variance weighted	23	0.0284680	0.0414013	0.4916978
Simple mode	23	0.0742018	0.1023865	0.4762601
Weighted mode	23	0.0139187	0.0637282	0.8291253

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.31532	21	0.2780326
Inverse variance weighted	24.77283	22	0.3080611

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038165	0.0060714	0.5363917

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007668	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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