Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 384)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1677286	0.1055675	0.1270424
Weighted median	23	-0.0121695	0.0582830	0.8346038
Inverse variance weighted	23	-0.0011915	0.0431163	0.9779541
Simple mode	23	-0.1244383	0.1206831	0.3136898
Weighted mode	23	0.0379235	0.0789559	0.6357467

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.48794	21	0.3185245
Inverse variance weighted	26.86800	22	0.2162828

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0103734	0.0059672	0.0967824

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008142	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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