Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 383)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0756708	0.0998208	0.4568346
Weighted median	23	-0.0224419	0.0537383	0.6762293
Inverse variance weighted	23	0.0084851	0.0390158	0.8278360
Simple mode	23	-0.0678238	0.0855964	0.4366076
Weighted mode	23	-0.0452952	0.0676640	0.5101972

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.87571	21	0.6568558
Inverse variance weighted	18.41041	22	0.6813970

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041259	0.0056424	0.4727182

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005593	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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