Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 382)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0358857	0.0998207	0.7228096
Weighted median	23	0.0534177	0.0564352	0.3438774
Inverse variance weighted	23	0.0586567	0.0390156	0.1327319
Simple mode	23	0.0589250	0.0828203	0.4842631
Weighted mode	23	0.0534114	0.0618574	0.3972011

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.88569	21	0.7760390
Inverse variance weighted	16.94448	22	0.7664187

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058058	0.0056423	0.3151972

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000582	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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