Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 381)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0324682	0.1114822	0.7737239
Weighted median	23	-0.0087903	0.0623153	0.8878215
Inverse variance weighted	23	-0.0220117	0.0425824	0.6052111
Simple mode	23	0.0030976	0.1096780	0.9777233
Weighted mode	23	-0.0102526	0.0874340	0.9077168

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.19380	21	0.1991558
Inverse variance weighted	26.20675	22	0.2429112

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006421	0.0063016	0.9198018

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008037	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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