Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 380)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0239628	0.1245862	0.8493243
Weighted median	23	-0.0960294	0.0601147	0.1101686
Inverse variance weighted	23	-0.0508569	0.0476384	0.2857187
Simple mode	23	-0.2081794	0.1231165	0.1049736
Weighted mode	23	-0.1217636	0.0738857	0.1135624

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.71418	21	0.0494840
Inverse variance weighted	32.79987	22	0.0647451

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016516	0.0070423	0.8168498

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010454	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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