Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 38)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1154682	0.0998196	0.2603570
Weighted median	23	-0.1005062	0.0598356	0.0930147
Inverse variance weighted	23	-0.0789035	0.0390153	0.0431380
Simple mode	23	-0.0654224	0.1094749	0.5562074
Weighted mode	23	-0.0170940	0.0918337	0.8540404

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.48188	21	0.7980194
Inverse variance weighted	15.64026	22	0.8333299

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022454	0.0056423	0.6946725

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005979	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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