Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 379)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1658738	0.1140665	0.1606788
Weighted median	23	0.0154979	0.0581862	0.7899696
Inverse variance weighted	23	-0.0014321	0.0461171	0.9752275
Simple mode	23	-0.0504585	0.1213268	0.6815199
Weighted mode	23	0.0496510	0.0686960	0.4774384

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.42253	21	0.1573014
Inverse variance weighted	30.73836	22	0.1015949

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0102743	0.0064476	0.1259891

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009314	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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