Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 378)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0776907	0.0998204	0.4450704
Weighted median	23	-0.0491278	0.0573485	0.3916362
Inverse variance weighted	23	-0.0450235	0.0390156	0.2485063
Simple mode	23	0.0657395	0.1021501	0.5265148
Weighted mode	23	-0.0312610	0.0703651	0.6611881

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.18896	21	0.8613466
Inverse variance weighted	15.97278	22	0.8172346

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0075359	0.0056423	0.1959777

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005244	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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