Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 377)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0156240	0.1062776	0.8845257
Weighted median	23	0.0078865	0.0596899	0.8948861
Inverse variance weighted	23	-0.0074068	0.0405913	0.8552124
Simple mode	23	0.0047263	0.1147875	0.9675282
Weighted mode	23	0.0366163	0.0755546	0.6327261

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.80519	21	0.3025929
Inverse variance weighted	23.81319	22	0.3570972

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005046	0.0060073	0.9338518

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007227	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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