Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 376)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0178862	0.1057136	0.8672624
Weighted median	23	0.0309408	0.0594141	0.6025303
Inverse variance weighted	23	0.0111733	0.0403734	0.7819719
Simple mode	23	0.0435776	0.0978606	0.6604516
Weighted mode	23	0.0250889	0.0677556	0.7147107

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.55263	21	0.3152356
Inverse variance weighted	23.55797	22	0.3708187

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004122	0.0059754	0.9456514

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007164	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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