Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 375)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1910768	0.0998189	0.0693155
Weighted median	23	0.0405493	0.0614458	0.5093051
Inverse variance weighted	23	0.0046954	0.0395299	0.9054482
Simple mode	23	0.0849646	0.1173163	0.4765533
Weighted mode	23	0.0765626	0.1008325	0.4557295

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.04397	21	0.6462198
Inverse variance weighted	22.58419	22	0.4255176

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0120224	0.0056423	0.0450895

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006848	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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