Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 373)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0236930	0.0998205	0.8146807
Weighted median	23	-0.0134680	0.0556247	0.8086851
Inverse variance weighted	23	0.0018603	0.0390156	0.9619697
Simple mode	23	-0.0078593	0.0961787	0.9356119
Weighted mode	23	-0.0242113	0.0705992	0.7348982

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.46927	21	0.5550642
Inverse variance weighted	19.52573	22	0.6126794

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013407	0.0056423	0.8144772

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005918	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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