Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 372)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0978282	0.1077749	0.3743314
Weighted median	23	0.0708806	0.0549948	0.1974467
Inverse variance weighted	23	0.0139374	0.0418510	0.7391156
Simple mode	23	0.0992750	0.0952609	0.3086651
Weighted mode	23	0.0896726	0.0574854	0.1330492

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.48039	21	0.2703692
Inverse variance weighted	25.31405	22	0.2822936

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0051517	0.006092	0.4072753

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007709	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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