Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 371)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0176649	0.0998207	0.8612308
Weighted median	23	0.0536155	0.0556917	0.3356879
Inverse variance weighted	23	0.0453129	0.0390155	0.2454766
Simple mode	23	0.0580304	0.0970900	0.5561452
Weighted mode	23	0.0527506	0.0659745	0.4325143

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.70073	21	0.5402815
Inverse variance weighted	19.79128	22	0.5960936

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016979	0.0056423	0.766439

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006406	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8