Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 370)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1392137	0.0998200	0.1777014
Weighted median	23	0.0672062	0.0542466	0.2153820
Inverse variance weighted	23	0.0593787	0.0390156	0.1280285
Simple mode	23	0.0717837	0.0815831	0.3884323
Weighted mode	23	0.0654204	0.0620871	0.3034611

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.40508	21	0.6862778
Inverse variance weighted	18.16009	22	0.6964557

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049026	0.0056423	0.3947184

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006205	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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