Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 37)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0332095	0.0998196	0.7426627
Weighted median	23	-0.0597291	0.0611825	0.3289431
Inverse variance weighted	23	-0.0320405	0.0390153	0.4115160
Simple mode	23	-0.0439186	0.1034924	0.6754204
Weighted mode	23	-0.0714059	0.0735844	0.3423985

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.84506	21	0.5310937
Inverse variance weighted	20.34940	22	0.5611939

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004007	0.0056423	0.485409

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006371	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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