Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 369)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1182639	0.1036951	0.2669200
Weighted median	23	-0.0837369	0.0560062	0.1348791
Inverse variance weighted	23	-0.0922376	0.0396682	0.0200597
Simple mode	23	-0.0150840	0.0971566	0.8780361
Weighted mode	23	-0.0747092	0.0615837	0.2379445

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.66201	21	0.3622607
Inverse variance weighted	22.74225	22	0.4164043

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015983	0.0058613	0.7877623

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008585	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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