Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 368)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1275241	0.0998190	0.2153506
Weighted median	23	-0.0091919	0.0577234	0.8734799
Inverse variance weighted	23	-0.0072127	0.0390155	0.8533336
Simple mode	23	0.1240585	0.1101656	0.2722543
Weighted mode	23	0.0158998	0.0808102	0.8458261

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.70345	21	0.5401086
Inverse variance weighted	21.41814	22	0.4950406

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073884	0.0056423	0.2045235

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006501	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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