Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 367)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0783293	0.1114278	0.4898007
Weighted median	23	-0.0601405	0.0598341	0.3148386
Inverse variance weighted	23	-0.0229407	0.0435274	0.5981664
Simple mode	23	-0.0331690	0.1056699	0.7565595
Weighted mode	23	-0.0302147	0.0748850	0.6904888

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.16794	21	0.2001178
Inverse variance weighted	27.38279	22	0.1970471

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006219	0.0062984	0.3346949

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008402	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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